{"id":225,"date":"2018-04-18T16:13:57","date_gmt":"2018-04-18T14:13:57","guid":{"rendered":"http:\/\/www.parsum.de\/en\/?page_id=225"},"modified":"2019-12-02T10:38:30","modified_gmt":"2019-12-02T09:38:30","slug":"granulation","status":"publish","type":"page","link":"https:\/\/www.parsum.de\/en\/processes\/granulation\/","title":{"rendered":"Granulation"},"content":{"rendered":"

[vc_row css=”.vc_custom_1513177939472{padding-top: 70px !important;}”][vc_column][vc_column_text]Granulates are produced in very varied processes. Parsum makes it possible to carry out inline monitoring of these processes and allows for the real-time visualisation of granulate growth in batch processes or constant product quality in continuous processes. Critical parameters for these processes, such as spray rate, temperature, air volume, contact pressure, rotational speed, binder amounts, etc., can be controlled and optimised for the specific product. The final granulate size can therefore be accurately defined and the process time for batch processes can be reduced. In continuous processes, trends and quality fluctuations can be detected at an early stage.[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=”20″ equal_height=”yes” bg_type=”bg_color” bg_override=”full” main_heading=”Leitbild” main_heading_color=”” heading_tag=”h2″ sub_heading_color=”” alignment=”center” spacer=”line_only” spacer_position=”middle” spacer_img_width=”48″ line_style=”solid” line_height=”5″ line_color=”” line_icon_fixer=”10″ main_heading_font_size=”desktop:30px;” main_heading_line_height=”desktop:36px;” el_class=”accent-border-color” sub_heading_font_family=”font_family:|font_call:” main_heading_style=”font-weight:bold;” sub_heading_style=”font-weight:700;” line_width=”200″ spacer_margin=”margin-bottom:30px;” main_heading_margin=”margin-bottom:5px;” main_heading_typograpy=”” main_heading_font_family=”” margin_design_tab_text=”” sub_heading_typograpy=”” sub_heading_font_size=”” sub_heading_line_height=”” sub_heading_margin=”” spacer_img=”” bg_color_value=”#f5f5f5″ css=”.vc_custom_1513178634700{padding-top: 20px !important;padding-bottom: 20px !important;}”][vc_column width=”1\/3″ css=”.vc_custom_1513178564410{background-color: #ffffff !important;}”]

Fluidised-bed batch granulation<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]The monitoring of granulate growth in fluidised-bed batch granulation using the IPP 70 in a laboratory-scale application helps give operators a better understanding of processes to design them more effectively and to optimise the definition of parameters. Fewer tests and laboratory analyses when upscaling means that development time is reduced.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467725-a626da5f-2726-2″ include=”229,230″][vc_single_image image=”380″ img_size=”large” onclick=”custom_link” img_link_target=”_blank” lazy_loading=”true” link=”https:\/\/www.youtube.com\/watch?v=IF-3L-3PEA4″][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1513178131677{background-color: #ffffff !important;}”]

Fluidised-bed granulation<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]Continuous particle size measurement using the Parsum probe during fluidised-bed granulation provides added certainty regarding the course of the process during routine production and helps to detect errors at an early stage and document the course of the process.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467727-89482c0e-d0f6-0″ include=”231,232″][vc_column_text]Download PDF: Inline-Partikelmessung in der Wirbelschicht<\/a>[\/vc_column_text][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1513179132654{background-color: #ffffff !important;}”]

Continuous agglomeration<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]Measurement after a rotary feeder in the continuous agglomeration of detergent. Inline particle measurement shortens the start-up phase and helps the operator keep the process stable.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467728-ba2db1fb-fab8-10″ include=”233,234″][vc_column_text]Download PDF: Inline-Messung der Partikelgr\u00f6\u00dfen sorgt bei Kontiproduktion f\u00fcr dauerhaft hohe Qualit\u00e4t<\/a>[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=”20″ equal_height=”yes” bg_type=”bg_color” bg_override=”full” main_heading=”Leitbild” main_heading_color=”” heading_tag=”h2″ sub_heading_color=”” alignment=”center” spacer=”line_only” spacer_position=”middle” spacer_img_width=”48″ line_style=”solid” line_height=”5″ line_color=”” line_icon_fixer=”10″ main_heading_font_size=”desktop:30px;” main_heading_line_height=”desktop:36px;” el_class=”accent-border-color” sub_heading_font_family=”font_family:|font_call:” main_heading_style=”font-weight:bold;” sub_heading_style=”font-weight:700;” line_width=”200″ spacer_margin=”margin-bottom:30px;” main_heading_margin=”margin-bottom:5px;” main_heading_typograpy=”” main_heading_font_family=”” margin_design_tab_text=”” sub_heading_typograpy=”” sub_heading_font_size=”” sub_heading_line_height=”” sub_heading_margin=”” spacer_img=”” bg_color_value=”#f5f5f5″ css=”.vc_custom_1513178634700{padding-top: 20px !important;padding-bottom: 20px !important;}”][vc_column width=”1\/3″ css=”.vc_custom_1513178564410{background-color: #ffffff !important;}”]

High-shear granulation process<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]Parsum probes track particle growth during highly dynamic high-shear granulation processes. This means that the granulation endpoint can be determined reliably and better batch-to-batch consistency can be achieved.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467729-20727bd6-240e-8″ include=”235,236″][vc_column_text]Download PDFs: Kutz, G., Kamke, D., Innovativer Ansatz zur Prozesskontrolle bei der Granulation im Intensivmischergranulator, Teil 1<\/a>, TechnoPharm 6, Nr.4, 2016, 234-239 und Teil 2<\/a>, TechnoPharm 6, Nr.5, 2016, 290-294[\/vc_column_text][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1513178131677{background-color: #ffffff !important;}”]

Roller compacting<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]The Parsum probe allows for continuous process monitoring during roller compacting and means that errors can be detected at an early stage.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467730-f690df53-8cc1-1″ include=”238,237″][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1513179132654{background-color: #ffffff !important;}”]

Melt granulation<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]Parsum probe IPP 80 can be used to investigate the granulability of different formulations effectively in a 4-litre laboratory mixer and to determine process parameters.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467731-70907290-713f-10″ include=”239″][vc_column_text]Download PDF: Real time particle size measurement during high-shear melt granulation<\/a>[\/vc_column_text][\/vc_column][\/vc_row][vc_row gap=”20″ equal_height=”yes” bg_type=”bg_color” bg_override=”full” main_heading=”Leitbild” main_heading_color=”” heading_tag=”h2″ sub_heading_color=”” alignment=”center” spacer=”line_only” spacer_position=”middle” spacer_img_width=”48″ line_style=”solid” line_height=”5″ line_color=”” line_icon_fixer=”10″ main_heading_font_size=”desktop:30px;” main_heading_line_height=”desktop:36px;” el_class=”accent-border-color” sub_heading_font_family=”font_family:|font_call:” main_heading_style=”font-weight:bold;” sub_heading_style=”font-weight:700;” line_width=”200″ spacer_margin=”margin-bottom:30px;” main_heading_margin=”margin-bottom:5px;” main_heading_typograpy=”” main_heading_font_family=”” margin_design_tab_text=”” sub_heading_typograpy=”” sub_heading_font_size=”” sub_heading_line_height=”” sub_heading_margin=”” spacer_img=”” bg_color_value=”#f5f5f5″ css=”.vc_custom_1513178634700{padding-top: 20px !important;padding-bottom: 20px !important;}”][vc_column width=”1\/3″ css=”.vc_custom_1513178564410{background-color: #ffffff !important;}”]

Drum granulation<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]The IPP 70 tracks the size increase of starter particles during drum granulation, meaning that the target particle size can be accurately complied with without having to interrupt the process for sampling and laboratory analysis.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467732-5db6b7c8-4685-0″ include=”241,240″][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1513178131677{background-color: #ffffff !important;}”]

Extrusion \/ twin-screw granulation<\/h2><\/div>
<\/span><\/div><\/div>[vc_column_text]The Parsum probe allows for the continuous measurement of the particle size distribution at the outlet of a twin-screw granulator and therefore provides important measured values for the development of control strategies for continuous pharmaceutical production processes.[\/vc_column_text][vc_media_grid element_width=”6″ gap=”15″ grid_id=”vc_gid:1575279467733-c98e6acd-fe55-10″ include=”242,243″][\/vc_column][vc_column width=”1\/3″][\/vc_column][\/vc_row][vc_row bg_type=”bg_color” bg_override=”full” bg_color_value=”#f5f5f5″][vc_column][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css=”.vc_custom_1513177939472{padding-top: 70px !important;}”][vc_column][vc_column_text]Granulates are produced in very varied processes. Parsum makes it possible to carry out inline monitoring of these processes and allows for the real-time visualisation of granulate growth in batch processes or constant product quality in continuous processes. Critical parameters for these processes, such as spray rate, temperature, air volume, contact pressure,…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":43,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-225","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nGranulation - Parsum EN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.parsum.de\/en\/processes\/granulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulation - Parsum EN\" \/>\n<meta property=\"og:description\" content=\"[vc_row css=”.vc_custom_1513177939472{padding-top: 70px !important;}”][vc_column][vc_column_text]Granulates are produced in very varied processes. 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